Ten-year-old orphan twins Wally and Cheyenne Shluffmuffins have a hard time at Cincinnati's Jolly Days orphanage, but things get much worse when the Mandible sisters offer to share their home in the Dripping Fang Forest.

Although a paid assassin is stalking Wally while his twin sister Cheyenne is under the power of the queen ont, it is up to them, their vampire Dad, and their friends to save the human race from the giant onts.