Resolving to become the world's greatest stand-up comedian despite less-than-funny challenges in his life, wheelchair-bound middle school student Jamie Grimm endures bullying from his mean-spirited cousin and hopes he will be fairly judged when he enters a local comedy contest.

Rafe Khatchadorian's new year at middle school is starting to look depressingly like the old one, except that art class is going well--and when he joins the flag-football team and demonstrates some talent as a running-back, he discovers a way of dealing with his bullying nemesis and teammate, Miller the Killer.