A reckless young mouse named Ralph makes friends with a boy in room 215 of the Mountain View Inn and discovers the joys of motorcycling.

Recently, Ramona Quimby has been following Henry Huggins on his newspaper route, embarrassing him in front of his customers and his friends. The day Ramona follows Henry to his "No girls allowed" clubhouse, she almost puts an end to his newspaper career forever.

Ramona's year in third grade is highlighted by the arrival of Howie's rich uncle, a change in her after-school situation, a surprise wedding, a death and a new arrival in the family, and her father's getting a job.