Led by Duncan "Gluestick" Dewey, the NERDS team uses brain power and courage rather than gadgets when they face off against supervillian Simon, his band of savage squirrels, and Albert, a middle-aged computer genius who lives with his mother.
When Ms. Information kidnaps the President's daughter, it is up to twelve-year-old Ruby, also known as Pufferfish, to use her super-nanobyte-enhanced allergies in leading the NERDS' investigation.
When a former member of NERDS turns into a villainous cheerleader, Matilda "Wheezer" Choi and the rest of the NERDS must infiltrate the cheerleader squad and save the world from a machine that wreaks havoc by entering other dimensions.
While running a spy network from their elementary school, five unpopular misfits combine their enhanced abilities and use cutting-edge gadgetry to fight evil around the world.