When Professor Pippy P. Poopypants comes to Jerome Horwitz Elementary School to teach science, and he goes off the deep end because students make fun of his name, only Captain Underpants can save the school from the professor's perilous plot.

General Jackrabbit and his Robo-Rabbits from Jupiter attempt to take over the world on Ricky Ricotta's birthday.

Infuriated by the declaration that Pluto is no longer a planet, President Penguin and his penguins invade Earth and it is up to Ricky and his robot pal to defeat them--with some help from Ricky's cousin Lucy and her pets.

A small mouse and his best friend, a giant flying robot, attempt to save the Earth when an evil Martian monkey and his mechanical creations attack.

George, Harold, Captain Underpants, and Sulu the Bionic Hamster battle the three Ridiculous Robo-Boogers in an attempt to turn the Bionic Booger Boy back into Melvin Sneedly.

Whenever Dragon wakes up groggy, he always does everything wrong, like sweeping a hole in his dirt floor, or reading an egg and frying his newspaper.

A small mouse named Ricky Ricotta and his best friend, a giant flying robot, save the world from Victor Von Vulture and his vicious voodoo vultures from Venus.

George and Harold have really done it this time--they've created a monster! She's faster, smarter, and more evil than anything the world has seen before--she's Wedgie Woman! With the help of her horrible robots and her horrendous hairdo, Wedgie Woman is on a mission to take over the world, and she'll give a whopping wedgie to anyone who stands in her way--including Captain Underpants.

Irrepressible friends George and Harold create a new comic book superhero, Super Diaper Baby.

The world's most evil corporation of the future invades Caveland, Ohio and enslaves the inhabitants, until a time portal takes Ook and Gluk to the year 2222, where they meet a wise new friend who provides them with the means of saving the day.