Twins Maureen and Francine try to distinguish themselves for the first time by pursing separate interests at the beginning of the sixth grade.

Ten-year-old Auggie Pullman, who was born with extreme facial abnormalities and was not expected to survive, goes from being home-schooled to entering fifth grade at a private middle school in Manhattan, which entails enduring the taunting and fear of his classmates as he struggles to be seen as just another student.

When Mia arrives at her new school, her goal is to be open to and friendly with everyone, but everyone at Park Street School fits into a clique. When the Popular Girls Club takes an interest in Mia's awesome fashion style and wants to recruit her, Mia must decide between them and her great new Cupcake Club friends. It's like choosing between her divorced mom and dad and her old house and new house. Is it always going to be Mia in the middle, or can...

Although Mia feels fairly satisfied with her life, she worries about who should attend parent-teacher night and her failing grade in Spanish.

Seventh-grader Georges adjusts to moving from a house to an apartment, his father's efforts to start a new business, his mother's extra shifts as a nurse, being picked on at school, and Safer, a boy who wants his help spying on another resident of their building.

Twelve-year-old Fisher Bas, a science-loving bully magnet, clones himself, only to discover that his double is infinitely cooler than himself.

As Nikki plans how she's going to spend her summer, things get more complicated after she starts hanging out with a visiting student.

"Twelve-year-old Jacky "Ha-Ha" Hart is a class clown with a penchant for pranking--and when she's required to act in the school play to appease her frustrated teachers, she must conquer her stutter"--

Amerlia thought that the only thing better than a best friend was two best friends. But then they come together and she's not sure if any of them are friends. Will Amelia be able to have more than one best friend?

When Rafe Kane enters middle school, he teams up with his best friend, "Leo the Silent," to create a game to make school more fun by trying to break every rule in the school's code of conduct.